Description

Avermectin B1A, Epi- CAS NO 106434-14-4 is a specific stereoisomer of the potent macrocyclic lactone, Avermectin B1a, distinguished by the epimerization at a key carbon center. This precise chemical structure is critical for advanced research and development in pharmaceutical chemistry and agrochemical science. It serves as a high-value reference standard and a key synthetic intermediate for scientists and manufacturers in the life sciences sector.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of avermectin derivatives in drug development and quality control laboratories.
• Metabolite Studies: Essential for investigating the metabolic pathways, degradation products, and environmental fate of avermectin-based compounds.
• Agrochemical Research: Serves as a critical intermediate in the synthesis and study of novel, more potent or selective parasiticides and insecticides.
• Analytical Method Development: Employed to develop and validate precise HPLC, LC-MS, and other chromatographic methods for avermectin detection.
• Structure-Activity Relationship (SAR) Research: Provides a defined molecular scaffold for studying how specific stereochemistry influences biological activity against parasites.
• Veterinary and Human Medicine R&D: Used in the research of next-generation anti-parasitic agents targeting a wide range of nematodes and arthropods.

Basic Information

Product Name	Avermectin B1A, Epi-
CAS No.	106434-14-4
Molecular Formula	C48H72O14
Molecular Weight	873.1 g/mol
Synonyms	Epi-Avermectin B1a; 4"-Epi-avermectin B1a; (4"R)-Avermectin B1a; Avermectin B1a epimer; 5-O-Demethyl-4"-epi-avermectin A1a; 22,23-Dihydro-4"-epi-avermectin B1a (partial); MK-244 epimer; Ivermectin precursor epimer
EINECS	Contact for details

Quality Control

Every batch of Avermectin B1A, Epi- is produced and analyzed under strict quality management protocols. Our products undergo rigorous purity and identity verification using advanced analytical techniques including HPLC, MS, and NMR to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic data is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.