Description

3-Iodopropyl-1-Trifluoromethanesulfonate is a versatile and highly reactive organoiodine building block, specifically a functionalized alkyl triflate. This compound is valued for its dual functionality, serving as an excellent electrophile for nucleophilic substitution reactions and a precursor for further synthetic transformations. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures, particularly in medicinal chemistry and ligand synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in creating alkylated amines, ethers, and sulfur-containing compounds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators that require specific alkyl-iodine motifs.
• Cross-Coupling Reactions: Serves as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Negishi, Stille) to form carbon-carbon bonds.
• Ligand and Catalyst Development: Employed in the preparation of specialized phosphine ligands, N-heterocyclic carbene (NHC) precursors, and other organometallic catalysts.
• Material Science Research: Useful for surface functionalization, polymer modification, and the synthesis of monomers for specialty polymers.
• Radiolabeling Precursor: The iodine moiety provides a potential handle for introducing radioactive isotopes (e.g., I-125) for diagnostic and research applications.

Basic Information

Product Name	3-Iodopropyl-1-Trifluoromethanesulfonate
CAS No.	106114-40-3
Molecular Formula	C4H6F3IO3S
Molecular Weight	325.05 g/mol
Synonyms	1-Iodo-3-(trifluoromethanesulfonyloxy)propane; 3-Iodopropyl Triflate; Propane, 1-iodo-3-[(trifluoromethyl)sulfonyl]oxy]-; Trifluoromethanesulfonic Acid 3-Iodopropyl Ester; 3-Iodo-1-propanol Triflate; 3-Iodopropyl Trifluoromethanesulfonate; 1-Iodo-3-(triflyloxy)propane
EINECS	Contact for details

Quality Control

Our 3-Iodopropyl-1-Trifluoromethanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.