Description

2-(Trimethylsilyl)Ethanesulfonyl Chloride is a specialized organosilicon sulfonylating reagent that provides a unique combination of reactivity and stability. This compound is valued for its role as a versatile protecting group and activating agent in complex organic synthesis, particularly for sensitive substrates. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the selective sulfonylation of amines and alcohols in the development of active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used as a protecting group for amino acids, offering orthogonal deprotection strategies in solid-phase and solution-phase peptide synthesis.
• Agrochemical Research: Employed in the synthesis of novel sulfonamide-based herbicides, fungicides, and plant growth regulators.
• Material Science Precursor: Serves as a building block for creating functionalized surfaces and silicon-containing polymers with specific sulfonyl properties.
• Cross-Coupling Reactions: Acts as an activating agent or directing group in palladium-catalyzed cross-coupling reactions to form carbon-carbon and carbon-heteroatom bonds.
• Chemical Biology Probes: Utilized to label biomolecules or create activity-based probes for studying enzyme function and protein interactions.

Basic Information

Product Name	2-(Trimethylsilyl)Ethanesulfonyl Chloride
CAS No.	106018-85-3
Molecular Formula	C5H13ClO2SSi
Molecular Weight	200.76 g/mol
Synonyms	2-(Trimethylsilyl)ethanesulfonyl chloride; (2-Trimethylsilyl)ethanesulfonyl chloride; 2-(Trimethylsilyl)ethylsulfonyl chloride; TES-Cl; 2-TMS-ethanesulfonyl chloride; 2-Trimethylsilylethanesulfonyl chloride; 2-(Trimethylsilyl)-1-ethanesulfonyl chloride; 106018-85-3
EINECS	Contact for details

Quality Control

Our 2-(Trimethylsilyl)Ethanesulfonyl Chloride is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.