Description

2-(2,2,2-Trifluoroethoxy)Ethanamine is a versatile fluorinated amine building block, offering a unique trifluoroethoxy side chain that imparts desirable properties like enhanced lipophilicity and metabolic stability to target molecules. This compound is critical for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where the introduction of fluorine atoms is a key strategy for optimizing biological activity. It is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system, anti-infectives, and oncology therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoroethoxy group can improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing their dielectric anisotropy and stability.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering surface properties, chemical resistance, and solubility.
• Organic Synthesis Reagent: Acts as a versatile amine nucleophile or protecting group precursor in complex multi-step synthetic routes in academic and industrial R&D.
• Fluorinated Surfactant Precursor: Used in the manufacture of specialty surfactants and surface-active agents for demanding industrial applications.

Basic Information

Product Name	2-(2,2,2-Trifluoroethoxy)Ethanamine
CAS No.	105939-65-9
Molecular Formula	C4H8F3NO
Molecular Weight	143.11 g/mol
Synonyms	2-(2,2,2-Trifluoroethoxy)ethylamine; 2,2,2-Trifluoroethyl 2-aminoethyl ether; 2-Aminoethyl 2,2,2-trifluoroethyl ether; 2-(Trifluoroethoxy)ethan-1-amine; 2-(2,2,2-Trifluoroethoxy)ethanamine hydrochloride (salt form); N-(2-(2,2,2-Trifluoroethoxy)ethyl)amine; TFEEA
EINECS	Contact for details

Quality Control

Our 2-(2,2,2-Trifluoroethoxy)Ethanamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (NMR, IR), to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent moisture absorption and degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%
Refractive Index	Contact for details
Density	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.