Description

(R)-Tetrahydro-2H-Pyran-2-Carboxylic Acid CAS NO 105499-34-1 is a high-value chiral building block and intermediate of significant importance in asymmetric synthesis. Its core value lies in its rigid, non-racemic structure, which is essential for imparting specific stereochemistry in the construction of complex molecules. This compound is critically needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure drugs, particularly in antiviral, anti-inflammatory, and central nervous system (CNS) therapeutic areas.
• Asymmetric Catalyst Ligand Precursor: Used in the preparation of chiral ligands for transition metal catalysis, enabling highly selective chemical transformations.
• Agrochemical Synthesis: Serves as a building block for creating chiral active ingredients in herbicides, fungicides, and insecticides with improved efficacy and environmental profile.
• Fine Chemical and Flavor/Fragrance Intermediate: Employed in the production of specialty chemicals and chiral components for advanced flavors and fragrances.
• Academic and R&D: A valuable reagent in medicinal chemistry and organic synthesis research for method development and exploring new chemical entities.
• Peptidomimetics and Bioactive Molecule Construction: Its carboxylic acid functionality and chiral center make it useful for designing peptide analogs and other bioactive compounds.

Basic Information

Product Name	(R)-Tetrahydro-2H-Pyran-2-Carboxylic Acid
CAS No.	105499-34-1
Molecular Formula	C6H10O3
Molecular Weight	130.14 g/mol
Synonyms	(R)-Tetrahydro-2H-pyran-2-carboxylic acid; (R)-Oxane-2-carboxylic acid; (2R)-Oxane-2-carboxylic acid; (R)-Tetrahydropyran-2-carboxylic acid; (R)-THP-2-CA; (R)-2-Carboxytetrahydropyran; (R)-Hexahydro-2H-pyran-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-Tetrahydro-2H-Pyran-2-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting customer specifications and industry standards. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.