Description

(6R,23S,25S)-5-o-Demethyl-28-Deoxy-25-(1,3-Dimethyl-1-Butenyl)-6,28-Epoxy-23-Hydroxymilbemycin B is a chemically modified derivative of the potent macrocyclic lactone, milbemycin B. This compound serves as a critical advanced intermediate in the synthesis of novel acaricidal and anthelmintic agents, offering a strategic building block for research and development. It is primarily utilized by pharmaceutical and agrochemical R&D teams focused on developing next-generation parasitic control solutions.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of novel milbemycin and avermectin analogs for crop protection and animal health.
• Veterinary Pharmaceutical Research: Used in the development of new endectocides and anthelmintics for livestock and companion animals.
• Parasitology Studies: Serves as a reference standard and active compound in mode-of-action and resistance mechanism research.
• Process Chemistry: Employed as a high-value intermediate in the optimization of synthetic routes for complex macrocyclic lactones.
• Biochemical Tool: Used to study glutamate-gated chloride channels (GluCls) in invertebrates.

Basic Information

Product Name	(6R,23S,25S)-5-o-Demethyl-28-Deoxy-25-(1,3-Dimethyl-1-Butenyl)-6,28-Epoxy-23-Hydroxymilbemycin B
CAS No.	104012-75-1
Molecular Formula	C₃₂H₄₆O₇
Molecular Weight	542.71 g/mol
Synonyms	5-O-Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-hydroxymilbemycin B; 23-Hydroxy-5-O-demethyl-28-deoxy-25-(3-methyl-1-butenyl)milbemycin B 6,28-epoxide; LL-F28249-α; Nematectin; Milbemycin B derivative; 6,28-Epoxy-23-hydroxy-5-O-demethyl-28-deoxy-25-(3-methyl-1-butenyl)milbemycin B
EINECS	Contact for details

Quality Control

Our (6R,23S,25S)-5-o-Demethyl-28-Deoxy-25-(1,3-Dimethyl-1-Butenyl)-6,28-Epoxy-23-Hydroxymilbemycin B is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, related substances, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.