Description

8A-Oxo-Avermectin B1A is a key oxidized derivative of the potent macrocyclic lactone, Avermectin B1a. This compound serves as a critical intermediate in the synthesis of novel, high-performance agrochemicals and veterinary pharmaceuticals. It is essential for manufacturers and R&D facilities focused on developing next-generation parasiticides and insecticides with enhanced efficacy and safety profiles.

Application

• Primary intermediate for the synthesis of advanced avermectin analogs and derivatives.
• Research and development of new-generation antiparasitic agents for agricultural and veterinary use.
• Key starting material in the production of high-value agrochemicals targeting mites, nematodes, and insects.
• Building block for pharmaceutical intermediates in the animal health sector.
• Reference standard for analytical method development and quality control in active ingredient manufacturing.
• Used in studies investigating structure-activity relationships (SAR) of macrocyclic lactones.

Basic Information

Product Name	8A-Oxo-Avermectin B1A
CAS No.	102190-68-1
Molecular Formula	C48H72O15
Molecular Weight	889.1 g/mol
Synonyms	8a-Oxoabamectin; 8a-Oxo-Avermectin B1a; 8a-Oxo-Avermectin B1 A; 8-Oxo-Avermectin B1a; 8a-Oxoavermectin B1a; 8a-Oxo-Avermectin B1 A; 5-O-Demethyl-8a-oxo-28-deoxy-6,28-epoxy-25-(1-methylpropyl)avermectin A1a; (2aE,4E,8E)-5-[(1R,2S,4S,5S,7S,10R,11S,12S,13S)-5-[(2S,4S,5S)-5-[(2S,4S,5S)-5-[(2S,4S,5S)-4-Hydroxy-5-methyloxan-2-yl]oxy-4-hydroxy-5-methyloxan-2-yl]oxy-4-hydroxy-5-methyloxan-2-yl]oxy-13-[(2R,5S,6S)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-2,11-dihydroxy-4,7,10,12-tetramethyl-9-oxo-3,14-dioxatetracyclo[10.3.1.0²,¹¹.0⁴,⁹]hexadec-5-en-8-yl]-2-methylbut-2-enoic acid
EINECS	Contact for details

Quality Control

Our 8A-Oxo-Avermectin B1A is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting specifications for use in synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.