Description

(R)-2-(Adamantan-1-Yl)-2-Aminoacetic Acid Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its rigid adamantane scaffold, which can impart metabolic stability and influence pharmacokinetic properties in drug molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas requiring enantiomerically pure intermediates for active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and synthesis of potential drug candidates, especially for central nervous system (CNS) and antiviral applications.
• Organic Synthesis Building Block: Used in asymmetric synthesis and medicinal chemistry to introduce the sterically bulky, lipophilic adamantyl group into target molecules.
• Peptidomimetics Research: Acts as a constrained amino acid analog in the design and study of peptide-like compounds with enhanced stability and bioavailability.
• Chemical Biology Probes: Employed in the development of molecular probes and tool compounds for studying biological pathways and target engagement.
• Catalyst and Ligand Development: Can be utilized in the preparation of chiral catalysts or ligands for enantioselective transformations.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(R)-2-(Adamantan-1-Yl)-2-Aminoacetic Acid Hydrochloride
CAS No.	101976-73-2
Molecular Formula	C₁₂H₂₀ClNO₂
Molecular Weight	245.74 g/mol
Synonyms	(R)-2-Adamantylglycine Hydrochloride; (R)-2-Amino-2-(adamantan-1-yl)acetic acid hydrochloride; D-Adamantylglycine HCl; (R)-1-Adamantylglycine Hydrochloride; (R)-α-Aminoadamantaneacetic Acid Hydrochloride; (R)-AADA HCl; (R)-2-(1-Adamantyl)glycine Hydrochloride
EINECS	Contact for details

Quality Control

Our production of (R)-2-(Adamantan-1-Yl)-2-Aminoacetic Acid Hydrochloride adheres to stringent quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing specific tests such as chiral purity (HPLC), assay, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.