Description

2H-Cyclopenta[B]Furan-2-One,Hexahydro-4-[(1E,3S,5S)-5-Methyl-3-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-1-Nonen-1-Yl]-5-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-, (3Ar,4R,5R,6As)- is a complex, stereochemically defined lactone derivative featuring multiple protected hydroxyl groups. This compound is a high-value synthetic intermediate prized for its precise molecular architecture, which is critical for constructing advanced chemical scaffolds. It is primarily sought after by research and development teams in the pharmaceutical and fine chemical industries for applications in medicinal chemistry and total synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for candidates targeting metabolic or neurological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore novel bioactive molecules.
• Asymmetric Synthesis: Employed as a sophisticated starting material or intermediate in stereoselective synthesis due to its multiple defined stereocenters and protecting groups.
• Fine Chemical Production: Utilized in the multi-step synthesis of specialty chemicals, fragrances, and advanced materials requiring high structural fidelity.
• Process Chemistry Development: Acts as a reference standard or intermediate for scaling up synthetic routes from laboratory to pilot plant scale.
• Academic & Institutional Research: Supports cutting-edge organic chemistry research in universities and institutes focused on natural product synthesis and methodology development.

Basic Information

Item	Details
Product Name	2H-Cyclopenta[B]Furan-2-One,Hexahydro-4-[(1E,3S,5S)-5-Methyl-3-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-1-Nonen-1-Yl]-5-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-, (3Ar,4R,5R,6As)-
CAS No.	101849-78-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(3aR,4R,5R,6aS)-Hexahydro-4-[(1E,3S,5S)-5-methyl-3-[(tetrahydro-2H-pyran-2-yl)oxy]-1-nonen-1-yl]-5-[(tetrahydro-2H-pyran-2-yl)oxy]-2H-cyclopenta[b]furan-2-one; Complex Lactone THP Ether; Stereoisomeric Lactone Intermediate; Protected Hydroxy Lactone Derivative; Chiral Bicyclic Lactone; Advanced Synthetic Building Block
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity intermediates. Every batch is characterized using advanced analytical techniques to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing specific results for chiral purity (HPLC), assay, and related substances are available upon request. We adhere to a cGMP-compliant quality management system where applicable to support our clients' regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep container tightly sealed when not in use to prevent moisture absorption or contamination.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.