Description

4,5-Dihydro-3-[2-Hydroxy-3,3,3-Trifluoro-2-(Trifluoromethyl)Propyl]-2(3H)-Furanone is a high-value, fluorinated lactone derivative that serves as a critical synthetic intermediate. Its unique structure, featuring a geminal bis(trifluoromethyl) hydroxypropyl group, makes it an essential building block for introducing trifluoromethyl motifs into complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its application enables the fine-tuning of physicochemical properties such as metabolic stability and lipophilicity in target compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Agrochemical Synthesis: Building block for advanced herbicides, fungicides, and insecticides where the introduction of fluorine atoms enhances biological activity and environmental stability.
• Advanced Material Research: Used in the development of specialty polymers and coatings to impart unique surface properties, such as oil and water repellency (oleophobicity/hydrophobicity).
• Liquid Crystal & Electronic Chemicals: Intermediate for fluorinated liquid crystal compounds and dielectric materials used in display technologies and electronics.
• Organic Synthesis & Catalysis: Serves as a versatile scaffold in asymmetric synthesis and as a ligand precursor in organometallic catalysis.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new methodologies in fluorination and the construction of fluorinated heterocycles.

Basic Information

Item	Details
Product Name	4,5-Dihydro-3-[2-Hydroxy-3,3,3-Trifluoro-2-(Trifluoromethyl)Propyl]-2(3H)-Furanone
CAS No.	101833-16-3
Molecular Formula	C9H8F6O3
Molecular Weight	278.15 g/mol
Synonyms	3-(2-Hydroxy-3,3,3-trifluoro-2-(trifluoromethyl)propyl)dihydrofuran-2(3H)-one; 2(3H)-Furanone, 4,5-dihydro-3-[2-hydroxy-3,3,3-trifluoro-2-(trifluoromethyl)propyl]-; Hexafluorinated lactone derivative; α-Hydroxy-α-(trifluoromethyl)-γ-butyrolactone derivative; 3-(1-Hydroxy-2,2,2-trifluoro-1-(trifluoromethyl)ethyl)dihydro-2(3H)-furanone; Fluorinated butyrolactone intermediate; Gem-bis(trifluoromethyl) hydroxypropyl lactone
EINECS	Contact for details

Quality Control

Our 4,5-Dihydro-3-[2-Hydroxy-3,3,3-Trifluoro-2-(Trifluoromethyl)Propyl]-2(3H)-Furanone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.