Description

(R)-6-(4-Aminophenyl)-4,5-Dihydro-5-Methyl-3(2H)-Pyridazinone is a chiral pyridazinone derivative of significant interest in advanced pharmaceutical synthesis. This compound serves as a critical chiral building block or intermediate for the development of novel active pharmaceutical ingredients (APIs). It is primarily required by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly in areas requiring stereochemical control.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, or anti-inflammatory agents.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective chemical reactions to construct complex molecular architectures.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs within R&D laboratories.
• Process Chemistry Development: Serves as a reference standard or a key material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Potential use in the development of biochemical tools and probes for studying enzyme mechanisms or biological pathways.

Basic Information

Product Name	(R)-6-(4-Aminophenyl)-4,5-Dihydro-5-Methyl-3(2H)-Pyridazinone
CAS No.	101328-85-2
Molecular Formula	C11H13N3O
Molecular Weight	203.24 g/mol
Synonyms	(R)-5-Methyl-6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone; (R)-6-(4-Aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone; (R)-5-Methyl-6-(p-aminophenyl)-2H-4,5-dihydropyridazin-3-one; (R)-enantiomer of 6-(4-Aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone; (R)-PD 151307 (related compound); (R)-Pyridazinone derivative; (R)-Aminophenyl dihydropyridazinone
EINECS	Contact for details

Quality Control

Our (R)-6-(4-Aminophenyl)-4,5-Dihydro-5-Methyl-3(2H)-Pyridazinone is manufactured under strict quality control protocols to ensure high chemical and chiral purity. Each batch is tested using advanced analytical techniques, including chiral HPLC, to confirm identity, potency, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere (e.g., nitrogen or argon) in a desiccator.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.