Description

[(1R,3Ar,4S,7Ar)-1-[(2S)-1-Iodopropan-2-Yl]-7A-Methyl-1,2,3,3A,4,5,6,7-Octahydroinden-4-Yl]Oxy-tert-Butyl-Dimethylsilane is a high-purity, advanced pharmaceutical intermediate characterized by its complex, stereochemically defined structure. This compound is of significant value in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of steroid-based therapeutics and other complex organic molecules. It is primarily sought after by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in process development and scale-up activities.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex steroid derivatives and other bioactive molecules.
• Organic Synthesis Research: Used in academic and industrial research for developing new synthetic methodologies, particularly those involving stereoselective reactions.
• Process Chemistry: Employed in the development and optimization of scalable synthetic routes for target drug candidates during clinical trial material production.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies to explore new therapeutic areas.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	[(1R,3Ar,4S,7Ar)-1-[(2S)-1-Iodopropan-2-Yl]-7A-Methyl-1,2,3,3A,4,5,6,7-Octahydroinden-4-Yl]Oxy-tert-Butyl-Dimethylsilane
CAS No.	100928-05-0
Molecular Formula	C19H35IOSi
Molecular Weight	434.48 g/mol
Synonyms	(1R,3aR,4S,7aR)-1-[(2S)-1-Iodopropan-2-yl]-7a-methyl-1,2,3,3a,4,5,6,7-octahydroinden-4-yloxy-tert-butyl-dimethylsilane; tert-Butyl((1R,3aR,4S,7aR)-1-((S)-1-iodopropan-2-yl)-7a-methyloctahydro-1H-inden-4-yloxy)dimethylsilane; TBDMS Ether of iodinated steroid intermediate; Steroid-TBDMS-Iodide intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical characterization, including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters. We support customer audits and can tailor specifications to meet the requirements of cGMP for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.