Description

6,8-Dichloroflavone is a synthetic, halogenated derivative of the flavonoid core structure, valued for its role as a potent and selective chemical probe in neuroscience research. This compound is primarily utilized as a high-affinity ligand for the benzodiazepine site of GABAA receptors, specifically modulating the α2 and α3 subtypes. It is therefore an essential research tool for pharmaceutical R&D and academic laboratories investigating anxiolytics, sedatives, and novel neurological therapeutics.

Application

• Neuroscience Research: Acts as a selective positive allosteric modulator for studying GABAA receptor subtypes α2 and α3.
• Pharmacological Probe Development: Serves as a key reference standard and lead compound in the discovery of non-sedative anxiolytic drugs.
• Biochemical Assays: Used in in vitro binding studies and functional assays to characterize receptor interactions and signal transduction pathways.
• Academic & Pharmaceutical R&D: A critical tool for understanding the structure-activity relationships (SAR) of flavone derivatives targeting the central nervous system.
• Reference Material: Employed as a high-purity analytical standard for method development and quality control in related synthetic chemistry projects.

Basic Information

Product Name	6,8-Dichloroflavone
CAS No.	100914-20-3
Molecular Formula	C15H8Cl2O2
Molecular Weight	291.13 g/mol
Synonyms	6,8-Dichloro-2-phenyl-4H-chromen-4-one; 6,8-Dichloro-2-phenyl-4H-1-benzopyran-4-one; 6,8-Dichloro-2-phenylchromone; NSC 339104; GABAA α2/3 Subtype Selective Agonist; Flavone, 6,8-dichloro-
EINECS	Contact for details

Quality Control

Our 6,8-Dichloroflavone is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for advanced research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible performance in your critical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.