Description

Triclabendazole Sulfoxide is a key pharmaceutical intermediate and metabolite of the anthelmintic agent triclabendazole. This compound is critical for the development and quality control of veterinary and human antiparasitic formulations targeting liver fluke infections. It is primarily utilized by manufacturers in the pharmaceutical and veterinary medicine industries for research, synthesis, and analytical standard applications. Its role is essential for ensuring the efficacy and safety of treatments against Fasciola hepatica and related parasitic diseases.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of the active pharmaceutical ingredient (API) triclabendazole and related anthelmintic compounds.
• Analytical Reference Standard: Used in high-performance liquid chromatography (HPLC), mass spectrometry (MS), and other analytical methods for quality control and quantification of triclabendazole in drug substances and products.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to study the absorption, distribution, metabolism, and excretion (ADME) of triclabendazole.
• Veterinary Pharmaceutical Manufacturing: Integral to the production of flukicide treatments for livestock, particularly cattle and sheep, to combat fascioliasis.
• Research & Development: Serves as a standard in bioanalytical and pharmacological research aimed at developing new formulations or improving existing anthelmintic therapies.
• Impurity Profiling: Used to identify and quantify sulfoxide-related impurities in triclabendazole API batches to ensure compliance with pharmacopeial standards (e.g., USP, EP).

Basic Information

Product Name	Triclabendazole Sulfoxide
CAS No.	100648-13-3
Molecular Formula	C14H9Cl3N2O2S
Molecular Weight	381.66 g/mol
Synonyms	5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole 1-Oxide; CGA 113201; 6-Chloro-5-(2,3-dichlorophenoxy)-2-(methylsulfinyl)-1H-benzimidazole; Triclabendazole Sulfoxide; Triclabendazole S-Oxide; Sulphoxide of Triclabendazole; Flukanex Sulfoxide; Fasinex Sulfoxide
EINECS	Contact for details

Quality Control

Our Triclabendazole Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of related substances and residual solvents. Certificates of Analysis (COA) detailing all test results against relevant specifications are provided to ensure traceability and compliance for pharmaceutical development and manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.