Description

1H-Pyrrolizine-2-Carboxaldehyde, Hexahydro-5-Oxo-, trans- (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound matters as a critical building block in the synthesis of complex molecules, offering a defined chiral center and reactive aldehyde moiety for further derivatization. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and novel chemical entities.
• Organic Synthesis Building Block: Utilized in research-scale and process chemistry for constructing pyrrolizine-based heterocyclic frameworks.
• Medicinal Chemistry Research: Serves as a versatile precursor for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed in catalytic asymmetric reactions due to its defined trans-configuration, enabling the production of enantiomerically pure compounds.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	1H-Pyrrolizine-2-Carboxaldehyde, Hexahydro-5-Oxo-, trans- (9Ci)
CAS No.	100447-27-6
Molecular Formula	C8H11NO2
Molecular Weight	153.18 g/mol
Synonyms	trans-Hexahydro-5-oxo-1H-pyrrolizine-2-carboxaldehyde; (2R,3aS,7aS)-rel-Octahydro-5-oxo-1H-pyrrolizine-2-carboxaldehyde; 1H-Pyrrolizine-2-carboxaldehyde, hexahydro-5-oxo-, trans-; 2-Formylhexahydro-5-oxo-1H-pyrrolizine; Hexahydro-5-oxo-1H-pyrrolizine-2-carbaldehyde, trans-
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolizine-2-Carboxaldehyde, Hexahydro-5-Oxo-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.