Description

1-(6-Chloropyridazin-3-yl)piperidin-4-amine dihydrochloride hydrate is a high-purity, synthetically versatile organic intermediate of significant importance in modern pharmaceutical research and development. Its core value lies in its piperidine-pyridazine hybrid structure, which serves as a privileged scaffold for constructing novel bioactive molecules. This compound is primarily needed by medicinal chemists and process development scientists within the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and metabolic conditions.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and combinatorial chemistry libraries due to its modifiable amine and chloropyridazine functional groups.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation herbicides and insecticides, leveraging the biological activity of the pyridazine moiety.
• Ligand Synthesis: Employed in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs) in material science applications.
• Chemical Biology Probes: Utilized to develop molecular probes for studying enzyme function and receptor interactions in biochemical assays.

Basic Information

Product Name	1-(6-Chloropyridazin-3-yl)piperidin-4-amine dihydrochloride hydrate
CAS No.	100241-10-9
Molecular Formula	C9H13ClN4 • 2HCl • 1.4H2O
Molecular Weight	~328.06 g/mol (anhydrous salt basis)
Synonyms	1-(6-Chloropyridazin-3-yl)-4-piperidinamine dihydrochloride hydrate; 4-Amino-1-(6-chloro-3-pyridazinyl)piperidine dihydrochloride hydrate; 1-(6-Chloro-3-pyridazinyl)-4-piperidinamine dihydrochloride hydrate; 6-Chloro-3-(4-amino-1-piperidinyl)pyridazine dihydrochloride hydrate; 100241-10-9 (CAS); 1-(6-Chloropyridazin-3-Yl)Piperidin-4-Amine 2HCl 1.4H2O
EINECS	Contact for details

Quality Control

Our production of 1-(6-Chloropyridazin-3-yl)piperidin-4-amine dihydrochloride hydrate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for water content, to ensure consistency and compliance with research-grade specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and meeting the exacting standards required for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	7.0 - 9.0 % (Theoretical for 1.4 H2O: ~7.7%)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.