Description

6-Vinyl-2,4,5,6,7,7A-Hexahydro-7A-Hydroxy-3,6-Dimethyl-α-Methylene-2-Oxo-5-Benzofuranacetic Acid Methyl Ester is a complex, high-value synthetic intermediate characterized by its unique fused benzofuran structure. This compound matters as a versatile chiral building block for the synthesis of advanced pharmaceutical agents and fine chemicals, offering significant value in creating molecules with specific stereochemistry. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and exploring new synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) or anti-inflammatory targets.
• Agrochemical Synthesis: Used in the development of advanced, stereospecific pesticides and herbicides where the specific spatial orientation of the molecule is critical for bioactivity.
• Fine Chemical Production: Serves as a precursor for complex fragrance and flavor ingredients that require specific stereochemical purity.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in asymmetric synthesis and natural product analog development.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating specialized polymers with unique thermal or optical properties.

Basic Information

Product Name	6-Vinyl-2,4,5,6,7,7A-Hexahydro-7A-Hydroxy-3,6-Dimethyl-α-Methylene-2-Oxo-5-Benzofuranacetic Acid Methyl Ester
CAS No.	19892-18-3
Molecular Formula	C₁₆H₂₂O₅
Molecular Weight	294.34 g/mol
Synonyms	Methyl 6-Vinyl-2,4,5,6,7,7a-hexahydro-7a-hydroxy-3,6-dimethyl-α-methylene-2-oxo-5-benzofuranacetate; 5-Benzofuranacetic acid, 2,4,5,6,7,7a-hexahydro-7a-hydroxy-3,6-dimethyl-α-methylene-2-oxo-6-vinyl-, methyl ester; Methyl (7aR)-6-ethenyl-7a-hydroxy-3,6-dimethyl-4,5,6,7-tetrahydro-2-benzofuran-2-carboxylate; 6-Vinyl-7a-hydroxy-3,6-dimethyl-4,5,6,7-tetrahydro-2-benzofuran-2-carboxylic acid methyl ester; A key lactone intermediate.
EINECS	Contact for details

Quality Control

Our 6-Vinyl-2,4,5,6,7,7A-Hexahydro-7A-Hydroxy-3,6-Dimethyl-α-Methylene-2-Oxo-5-Benzofuranacetic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be sensitive to prolonged exposure to heat, moisture, and strong light. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.