Description

1H-Pyrazole, 5-Ethynyl-1-Methyl- is a specialized heterocyclic building block featuring a pyrazole core functionalized with an ethynyl group. This compound is of significant value in advanced organic synthesis and medicinal chemistry due to its versatile reactivity, serving as a key intermediate for constructing complex molecular architectures. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of potential drug candidates, particularly in kinase inhibitor and other targeted therapy research.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic structure for bioactivity.
• Material Science: Serves as a monomer or cross-linking agent in the creation of specialized polymers and advanced organic materials.
• Chemical Synthesis: Utilized in click chemistry (e.g., copper-catalyzed azide-alkyne cycloaddition) and other coupling reactions due to the reactive ethynyl moiety.
• Academic & R&D: Employed in universities and corporate R&D labs for methodological studies and exploring new synthetic pathways.
• Ligand Synthesis: Acts as a precursor for creating novel ligands used in catalysis and coordination chemistry.

Basic Information

Product Name	1H-Pyrazole, 5-Ethynyl-1-Methyl-
CAS No.	19762-15-3
Molecular Formula	C6H6N2
Molecular Weight	106.12 g/mol
Synonyms	5-Ethynyl-1-methyl-1H-pyrazole; 1-Methyl-5-ethynylpyrazole; 5-Ethynyl-1-methylpyrazole; 1-Methyl-5-ethynyl-1H-pyrazole; 1-Methyl-5-(ethynyl)pyrazole; 5-Ethynyl-1-methyl-1H-pyrazole; 1-Methyl-5-ethynylpyrazole; 5-Ethynyl-1-methylpyrazole
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole, 5-Ethynyl-1-Methyl- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.