Description

Para-Nitrobenzylbromide CAS NO 19689-86-2 is a versatile and high-purity organic synthesis intermediate, primarily used as a key alkylating agent and protecting group reagent. Its value lies in its reactivity, which enables precise chemical transformations critical for building complex molecular architectures. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where it serves as a foundational building block for active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring benzyl-protected functional groups.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the nitro and benzyl bromide functionalities are leveraged for structural diversification.
• Peptide Chemistry: Acts as a protecting group reagent for carboxylic acids during solid-phase and solution-phase peptide synthesis.
• Material Science Research: Serves as a precursor for functionalized organic molecules used in organic electronics and polymer research.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of complex nitro-aromatic dyes and colorants.
• Cross-Coupling Reactions: Useful substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create biaryl structures.
• Alkylation Agent: Employed in organic synthesis to introduce the para-nitrobenzyl group into nucleophiles such as alcohols, thiols, and amines.
• Chemical Biology Probes: Used in the development of photoactivatable or cleavable linker systems for bioconjugation and probe design.

Basic Information

Item	Detail
Product Name	Para-Nitrobenzylbromide
CAS No.	19689-86-2
Molecular Formula	C7H6BrNO2
Molecular Weight	216.03 g/mol
Synonyms	4-Nitrobenzyl Bromide; p-Nitrobenzyl Bromide; α-Bromo-4-nitrotoluene; (4-Nitrophenyl)methyl Bromide; PNBB; 1-(Bromomethyl)-4-nitrobenzene; NSC 404088
EINECS	243-218-6

Quality Control

Our Para-Nitrobenzylbromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for critical B2B and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	98 - 102 °C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.