Description

3β-(Trimethylsiloxy)-5α-Cholestane is a high-purity steroidal derivative, specifically a cholestane silyl ether, valued for its role as a critical synthetic intermediate and analytical reference standard. Its primary commercial significance lies in enabling precise chemical transformations and serving as a benchmark in chromatographic and spectroscopic analysis within advanced research and development. This compound is essential for pharmaceutical chemists, analytical laboratories, and research institutions focused on steroid chemistry, drug discovery, and metabolic studies.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and novel drug candidates.
• Analytical Reference Standard: Used for method development, calibration, and quantification in Gas Chromatography (GC) and High-Performance Liquid Chromatography (HPLC) for sterol and steroid analysis.
• Biochemical Research: Employed in metabolic pathway studies, enzyme inhibition assays, and as a probe for investigating sterol biosynthesis and regulation.
• Derivatization Agent: Utilized to enhance the volatility and detectability of sterols and related compounds in mass spectrometric (MS) analysis.
• Material Science Research: Serves as a precursor or model compound in the development of novel organic materials and liquid crystals.

Basic Information

Product Name	3β-(Trimethylsiloxy)-5α-Cholestane
CAS No.	18880-51-8
Molecular Formula	C₃₀H₅₄OSi
Molecular Weight	458.8 g/mol
Synonyms	5α-Cholestan-3β-ol trimethylsilyl ether; Cholestane-3β-ol, trimethylsilyl ether; 3β-Trimethylsiloxy-5α-cholestane; 5α-Cholestan-3β-yloxytrimethylsilane; (3β)-3-[(Trimethylsilyl)oxy]-5α-cholestane; TMS-cholestanol; Trimethylsilyl cholestanol ether
EINECS	Contact for details

Quality Control

Every batch of 3β-(Trimethylsiloxy)-5α-Cholestane is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the exacting requirements of research and pharmaceutical development. A detailed Certificate of Analysis (COA) including results from HPLC, GC, NMR, and other relevant tests is supplied with each shipment to guarantee full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.