Description

4H-1,2,4-Triazole,4-(Trimethylsilyl)-(7Ci,8Ci,9Ci) is a specialized organosilicon derivative of the 1,2,4-triazole heterocycle, known by the CAS registry number 18827-14-0. This compound is valued as a versatile silylating agent and protected intermediate in advanced synthetic chemistry, enabling the introduction of the trimethylsilyl (TMS) group. It is primarily required by pharmaceutical, agrochemical, and material science research and development teams for constructing complex molecules, including active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key building block and protecting group reagent in the synthesis of novel drug candidates, particularly those containing triazole moieties.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where the triazole scaffold is critical for biological activity.
• Material Science Precursor: Acts as a monomer or functionalization agent in the development of specialty polymers, silicones, and advanced organic-inorganic hybrid materials.
• Organic Synthesis Reagent: Employed as a silylating agent to protect reactive sites or modify solubility and volatility properties of target molecules during multi-step synthesis.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for metal-organic frameworks (MOFs) or catalysts for asymmetric synthesis.
• Life Sciences Research: Functions as a biochemical probe or a tagged intermediate in medicinal chemistry and proteomics research.

Basic Information

Product Name	4H-1,2,4-Triazole,4-(Trimethylsilyl)-(7Ci,8Ci,9Ci)
CAS No.	18827-14-0
Molecular Formula	C5H11N3Si
Molecular Weight	141.25 g/mol
Synonyms	4-(Trimethylsilyl)-1H-1,2,4-triazole; 4-(Trimethylsilyl)-4H-1,2,4-triazole; 1H-1,2,4-Triazole, 4-(trimethylsilyl)-; 4-Trimethylsilyl-1,2,4-triazole; TMS-1,2,4-triazole; 4-TMS-1,2,4-triazole; 4-(Trimethylsilyl)-1,2,4-triazole
EINECS	Contact for details

Quality Control

Our 4H-1,2,4-Triazole,4-(Trimethylsilyl)-(7Ci,8Ci,9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, identity, and consistency, meeting the stringent requirements of research and process development. Certificates of Analysis (COA) detailing purity (typically by HPLC or GC), identity confirmation (by IR, NMR), and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area. For long-term stability, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Melting Point	Contact for details
Water Content (KF)	<0.5%
Residue on Ignition	<0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.