Description

H-D-Ser(Tbu)-Oh CAS NO 18783-53-4 is a protected serine derivative, specifically the tert-butyl ether of D-serine, widely used as a critical chiral building block in organic synthesis. This high-purity amino acid derivative is essential for constructing complex peptide sequences and other bioactive molecules with precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, diagnostics, and fine chemicals.

Application

• Peptide Synthesis: A key intermediate in solid-phase and solution-phase peptide synthesis (SPPS) for introducing D-serine residues.
• Pharmaceutical Research: Building block for the research and development of novel peptide drugs, hormones, and enzyme inhibitors.
• Bioconjugation: Used in the preparation of peptide-protein conjugates for antibody-drug conjugates (ADCs) and diagnostic probes.
• Chemical Biology: Tool compound for studying enzyme mechanisms and protein-protein interactions.
• Fine Chemical Production: Intermediate in the synthesis of complex organic molecules requiring chiral amino acid scaffolds.
• Protecting Group Strategy: The tert-butyl (Tbu) protecting group allows for orthogonal deprotection in multi-step synthetic routes.

Basic Information

Product Name	H-D-Ser(Tbu)-Oh
CAS No.	18783-53-4
Molecular Formula	C7H15NO3
Molecular Weight	161.20 g/mol
Synonyms	D-Serine, O-tert-butyl ether; (R)-2-Amino-3-(tert-butoxy)propanoic acid; H-D-Ser(OtBu)-OH; D-Ser(OtBu)-OH; Fmoc-D-Ser(OtBu)-OH precursor; Boc-D-Ser(OtBu)-OH precursor; D-3-(tert-Butoxy)alanine; D-Serine tert-butyl ether
EINECS	Contact for details

Quality Control

Our H-D-Ser(Tbu)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.