Description

Chlorpromazine Sulfone Hydrochloride is a high-purity pharmaceutical intermediate and reference standard of significant importance in chemical synthesis and analytical research. Its primary value lies in its role as a key derivative and metabolite of the antipsychotic drug Chlorpromazine, enabling critical studies in pharmacology and drug metabolism. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors who require precise and reliable materials for method development, quality control, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of Chlorpromazine and its related substances in drug products and biological samples.
• Metabolite Research: Critical for in-vitro and in-vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of Chlorpromazine.
• Impurity Standard: Serves as a well-characterized impurity standard for the analytical method validation and quality control of Chlorpromazine Active Pharmaceutical Ingredient (API) and finished dosage forms.
• Chemical Synthesis Intermediate: Employed as a building block in the research-scale synthesis of novel phenothiazine derivatives for pharmacological evaluation.
• Analytical Method Development: Utilized in developing and calibrating analytical techniques such as HPLC, LC-MS, and GC-MS for the detection of phenothiazine compounds.
• Regulatory Compliance Testing: Supports testing to meet stringent regulatory requirements (e.g., ICH guidelines) for impurity identification and control in pharmaceutical manufacturing.

Basic Information

Product Name	Chlorpromazine Sulfone Hydrochloride
CAS No.	18683-73-3
Molecular Formula	C17H19ClN2O2S • HCl
Molecular Weight	395.77 g/mol
Synonyms	2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine 5,5-Dioxide Hydrochloride; Chlorpromazine Sulphone Hydrochloride; Chlorpromazine Sulfone HCl; CPZ Sulfone Hydrochloride; 5,5-Dioxo-2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine Hydrochloride; 18683-73-3 (CAS); Chlorpromazine S,S-Dioxide Hydrochloride
EINECS	Contact for details

Quality Control

Our Chlorpromazine Sulfone Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profile analysis via advanced chromatographic methods. A Certificate of Analysis (COA) detailing all test results is provided with every shipment, supporting its use in GLP/GMP-compliant environments for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.