Description

(S)-2-Amino-3-(3,4,5-Trimethoxy-Phenyl)-Propionic Acid CAS NO 18652-97-6 is a non-natural, optically active amino acid derivative featuring a trimethoxyphenyl side chain. This compound matters as a sophisticated chiral building block, enabling the synthesis of complex molecules with high stereochemical purity for advanced research and development. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers working on novel active pharmaceutical ingredients (APIs), peptide mimetics, and other bioactive compounds where precise stereochemistry is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Peptidomimetics & Conformationally Restricted Peptides: Used to incorporate a rigid, aromatic side chain into peptide backbones to study structure-activity relationships and enhance metabolic stability.
• Asymmetric Synthesis: Serves as a starting material or chiral auxiliary in catalytic asymmetric reactions to construct complex molecular architectures.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to probe active sites and understand biological pathways.
• Ligand & Catalyst Development: Utilized for creating novel chiral ligands and organocatalysts for use in stereoselective transformations.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(S)-2-Amino-3-(3,4,5-Trimethoxy-Phenyl)-Propionic Acid
CAS No.	18652-97-6
Molecular Formula	C₁₂H₁₇NO₅
Molecular Weight	255.27 g/mol
Synonyms	(S)-2-Amino-3-(3,4,5-trimethoxyphenyl)propanoic acid; (S)-3,4,5-Trimethoxy-D-phenylalanine; D-(3,4,5-Trimethoxyphenyl)alanine; (S)-3-(3,4,5-Trimethoxyphenyl)alanine; (S)-α-Amino-3,4,5-trimethoxybenzenepropanoic acid; (S)-TMP; (S)-3,4,5-Trimethoxy-D-Phe; (S)-3,4,5-Trimethoxyphenylalanine
EINECS	Contact for details

Quality Control

Our (S)-2-Amino-3-(3,4,5-Trimethoxy-Phenyl)-Propionic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and cGMP-grade standards where applicable. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.