Description

Ethyl Trimethylsilyl Malonate is a versatile organosilicon reagent, specifically a silylated malonate ester, widely used as a key building block in organic synthesis. Its primary value lies in its dual functionality, serving as a protected malonate anion equivalent that enables efficient carbon-carbon bond formation under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is utilized for the synthesis of complex molecules, heterocycles, and fine chemicals.

Application

• Pharmaceutical Intermediates: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing β-keto ester and malonic acid derivatives.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require malonate-based molecular frameworks.
• Fine Chemical Manufacturing: Employed in Knoevenagel condensations, Michael additions, and other C-C bond-forming reactions to create specialty chemicals and flavors/fragrances.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of novel silicon-containing polymers and hybrid materials.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and catalysis studies.

Basic Information

Product Name	Ethyl Trimethylsilyl Malonate
CAS No.	18457-03-9
Molecular Formula	C10H20O4Si
Molecular Weight	232.35 g/mol
Synonyms	Diethyl (Trimethylsilyl)malonate; Trimethylsilyl Diethyl Malonate; Diethyl (Trimethylsilyl)propanedioate; Malonic Acid, Diethyl Ester, 2-(Trimethylsilyl)-; Ethyl 2-(Trimethylsilyl)malonate; Propanedioic Acid, 2-(Trimethylsilyl)-, Diethyl Ester; TMS-Diethyl Malonate; Diethyl (Trimethylsilyl)propanedioate
EINECS	Contact for details

Quality Control

Our Ethyl Trimethylsilyl Malonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.