Description

4-Chloro-(n-Boc)Aniline 97 is a high-purity, protected aniline derivative essential for advanced organic synthesis. This compound serves as a critical building block for introducing the 4-chloroaniline moiety into complex molecules under mild, orthogonal conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), intermediates, and novel chemical entities. Its Boc-protected amine group offers excellent stability and selective deprotection capabilities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research.
• Agrochemical Synthesis: Used in the development and production of herbicides, fungicides, and insecticides that require a halogenated aniline core structure.
• Peptide Mimetics & Conjugates: Facilitates the incorporation of aromatic, chloro-substituted amino acid analogs into peptide chains and bioconjugates.
• Material Science Research: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, dyes, and advanced organic materials.
• Cross-Coupling Reactions: Acts as a substrate in Buchwald-Hartwig amination and other palladium-catalyzed coupling reactions to form complex C-N bonds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.

Basic Information

Product Name	4-Chloro-(n-Boc)Aniline 97
CAS No.	18437-66-6
Molecular Formula	C11H14ClNO2
Molecular Weight	227.69 g/mol
Synonyms	4-Chloro-N-(tert-butoxycarbonyl)aniline; 1-(tert-Butoxycarbonylamino)-4-chlorobenzene; tert-Butyl (4-chlorophenyl)carbamate; N-Boc-4-chloroaniline; N-(tert-Butoxycarbonyl)-4-chloroaniline; 4-Chloroaniline N-Boc protected; Boc-4-Cl-Aniline; 4-Chlorophenylcarbamic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our 4-Chloro-(n-Boc)Aniline 97 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the specified 97% minimum purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.