Description

4-[(Trimethylsilyl)Amino]Benzoic Acid Trimethylsilyl Ester is a highly functionalized, silyl-protected benzoic acid derivative that serves as a versatile synthetic intermediate and protecting group reagent. This compound is particularly valuable for its dual silyl functionalities, which enhance solubility in organic media and provide orthogonal protection strategies in complex multi-step syntheses. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing and modifying complex molecular architectures.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly where amino and carboxylic acid groups require temporary protection.
• Peptide Chemistry: Acts as a protecting group for carboxylic acids during solid-phase peptide synthesis (SPPS) or solution-phase coupling reactions.
• Agrochemical Synthesis: Employed in the development of novel herbicides, fungicides, and plant growth regulators that contain functionalized benzoic acid cores.
• Liquid Crystal & OLED Materials: Serves as a key building block for creating advanced organic semiconductors and liquid crystal molecules due to its stable silyl groups and planar aromatic structure.
• Cross-Coupling Reactions: Functions as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck) after appropriate functional group manipulation.
• Silicon-Based Polymer Chemistry: Used as a monomer or modifier in the synthesis of specialized silicones and siloxane-based polymers.
• Chemical Derivatization Agent: Utilized in analytical chemistry to derivative sensitive compounds for Gas Chromatography (GC) or Mass Spectrometry (MS) analysis.

Basic Information

Product Name	4-[(Trimethylsilyl)Amino]Benzoic Acid Trimethylsilyl Ester
CAS No.	18406-05-8
Molecular Formula	C13H23NO2Si2
Molecular Weight	281.50 g/mol
Synonyms	4-(Trimethylsilylamino)benzoic Acid Trimethylsilyl Ester; Benzoic Acid, 4-[(trimethylsilyl)amino]-, Trimethylsilyl Ester; 4-(N-Trimethylsilylamino)benzoic Acid TMS Ester; p-[(Trimethylsilyl)Amino]Benzoic Acid Trimethylsilyl Ester; TMS-Protected 4-Aminobenzoic Acid; 4-Aminobenzoic Acid Bis(trimethylsilyl) Derivative; Bis(trimethylsilyl) 4-Aminobenzoate; 18406-05-8
EINECS	Contact for details

Quality Control

Our 4-[(Trimethylsilyl)Amino]Benzoic Acid Trimethylsilyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and Karl Fischer titration for moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.