Description

2-Methyl-4-Trimethylsilyl-1-Buten-3-Yne is a specialized organosilicon building block featuring a unique combination of a silyl-protected alkyne and an alkene moiety. This compound is valued for its role as a versatile synthon in advanced organic synthesis, particularly in the construction of complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as cross-coupling reactions and the synthesis of novel silicon-containing polymers.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring silicon incorporation or complex alkyne chemistry.
• Agrochemical Synthesis: Used in the research and development of new pesticides, herbicides, and plant growth regulators that utilize organosilicon chemistry for enhanced properties.
• Advanced Material Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, resins, and silicon-based materials with tailored thermal or optical characteristics.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form complex carbon-carbon bonds.
• Organic Synthesis Reagent: Employed in academic and industrial research laboratories for the construction of complex natural products and molecular scaffolds.
• Ligand and Catalyst Development: Useful in the synthesis of novel ligands for catalysis or as a precursor for metal-organic frameworks (MOFs) and other coordination compounds.

Basic Information

Item	Details
Product Name	2-Methyl-4-Trimethylsilyl-1-Buten-3-Yne
CAS No.	18387-60-5
Molecular Formula	C8H14Si
Molecular Weight	138.28 g/mol
Synonyms	1-Buten-3-yne, 2-methyl-4-(trimethylsilyl)-; 2-Methyl-4-(trimethylsilyl)-1-buten-3-yne; 4-Trimethylsilyl-2-methyl-1-buten-3-yne; TMS-protected methyl butenyne; Trimethyl(2-methyl-1-buten-3-yn-4-yl)silane
EINECS	Contact for details

Quality Control

Our 2-Methyl-4-Trimethylsilyl-1-Buten-3-Yne is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our commitment to cGMP principles and rigorous quality assurance ensures reliable performance for your critical synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed and stored upright. Keep away from heat, sparks, and open flames. For long-term storage, consider maintaining under an inert atmosphere such as nitrogen or argon to preserve stability.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.