Description

1,3-Bis(Trimethylsilyl)Urea is a versatile organosilicon reagent primarily used as a silylating agent. Its core value lies in its ability to efficiently introduce trimethylsilyl (TMS) protecting groups onto reactive functional groups like hydroxyls and amines, facilitating complex synthetic sequences. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise protection and deprotection steps are critical for synthesizing high-value intermediates and active ingredients.

Application

• Pharmaceutical Synthesis: Key reagent for protecting hydroxyl and amino groups during the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex natural products.
• Peptide Chemistry: Used as a silylating agent to protect amino acid side chains, enabling the controlled synthesis of peptides and peptidomimetics.
• Agrochemical Intermediate Production: Facilitates the synthesis of advanced pesticide and herbicide intermediates by protecting sensitive functional groups.
• Silicon-Based Polymer Chemistry: Serves as a monomer or modifying agent in the production of specialized silicones and silicon-containing polymers.
• Analytical Derivatization: Employed to derivative polar compounds for Gas Chromatography (GC) and Mass Spectrometry (MS) analysis, improving volatility and detection.
• Nucleoside and Carbohydrate Chemistry: Protects hydroxyl groups on sugar moieties during the synthesis of nucleosides, nucleotides, and modified carbohydrates.

Basic Information

Product Name	1,3-Bis(Trimethylsilyl)Urea
CAS No.	18297-63-7
Molecular Formula	C7H20N2OSi2
Molecular Weight	204.42 g/mol
Synonyms	BSU; 1,3-Bis(trimethylsilyl)urea; N,N'-Bis(trimethylsilyl)urea; Urea, 1,3-bis(trimethylsilyl)-; Urea, N,N'-bis(trimethylsilyl)-; Trimethylsilylurea; BTMSU; Hexamethyl-1,3-bis(trimethylsilyl)urea derivative
EINECS	Contact for details

Quality Control

Our 1,3-Bis(Trimethylsilyl)Urea is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including assay by titration and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (Titration)	≥ 98.0 %
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.