Description

1-Trimethylsilyl-1,2,4-Triazole is a versatile organosilicon reagent primarily used as a silylating agent and a key synthetic intermediate in advanced organic chemistry. Its value lies in its ability to introduce the trimethylsilyl (TMS) protecting group, facilitating complex multi-step syntheses with high selectivity and yield. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for nucleoside analogs and heterocyclic compounds.
• Silylating Agent: Used to protect reactive functional groups (e.g., hydroxyl, amino) during complex organic synthesis, improving reaction selectivity and product stability.
• Agrochemical Synthesis: Serves as a key intermediate in the production of advanced herbicides, fungicides, and plant growth regulators.
• Material Science Research: Employed in the development of novel silicon-containing polymers, coatings, and advanced electronic materials.
• Cross-Coupling Reactions: Acts as a reagent in palladium-catalyzed cross-coupling reactions for constructing complex molecular architectures.
• Laboratory Reagent: Used in research and development for method development and small-scale synthesis of specialty chemicals.

Basic Information

Product Name	1-Trimethylsilyl-1,2,4-Triazole
CAS No.	18293-54-4
Molecular Formula	C5H11N3Si
Molecular Weight	141.25 g/mol
Synonyms	1-(Trimethylsilyl)-1H-1,2,4-triazole; Trimethylsilyl-1,2,4-triazole; TMS-1,2,4-Triazole; 1,2,4-Triazole, 1-(trimethylsilyl)-; 1H-1,2,4-Triazole, 1-(trimethylsilyl)-; NSC 163063; 1-TMS-1,2,4-triazole; (1,2,4-Triazol-1-yl)trimethylsilane
EINECS	Contact for details

Quality Control

Our 1-Trimethylsilyl-1,2,4-Triazole is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.