Description

(1R,2S)-1,2-Diacetylcyclopropane CAS NO 18289-17-3 is a high-purity, stereochemically defined cyclopropane derivative featuring two acetyl substituents. This compound serves as a versatile and valuable chiral building block in advanced organic synthesis, enabling the construction of complex molecular architectures with precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in medicinal chemistry programs targeting novel therapeutic agents.
• Agrochemical Research: Used in the development of new pesticides and herbicides where the cyclopropane ring and specific stereochemistry are critical for biological activity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce the chiral cyclopropane motif into target molecules.
• Ligand and Catalyst Development: Serves as a precursor for the synthesis of novel chiral ligands and organocatalysts used in stereoselective transformations.
• Material Science Research: Investigated as a monomer or building block for creating polymers and advanced materials with unique structural properties.
• Academic & Industrial R&D: A fundamental tool for methodological studies in organic chemistry and process development within fine chemical manufacturing.

Basic Information

Product Name	(1R,2S)-1,2-Diacetylcyclopropane
CAS No.	18289-17-3
Molecular Formula	C7H10O2
Molecular Weight	126.15 g/mol
Synonyms	(1R,2S)-1,2-Diacetylcyclopropane; (1R,2S)-1,2-Di(acetyl)cyclopropane; (1R,2S)-1,2-Bis(acetyl)cyclopropane; (1R,2S)-1,2-Diketo-1,2-di(ethyl)cyclopropane; 1,2-Diacetylcyclopropane (enantiomer); cis-1,2-Diacetylcyclopropane (specified enantiomer); Chiral 1,2-Diacetylcyclopropane
EINECS	Contact for details

Quality Control

Our (1R,2S)-1,2-Diacetylcyclopropane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) specifying identity, purity (assay), enantiomeric excess (ee), and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.