Description

(E)-3-Trimethylsilanylbut-2-En-1-Ol is a valuable organosilicon intermediate featuring both a silyl-protected alcohol and an alkene functional group. This unique bifunctional structure makes it a versatile building block for synthesizing more complex molecules in fine chemical and pharmaceutical research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing silicon-containing or protected hydroxyl moieties.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where its functional groups allow for structural diversification.
• Organometallic Chemistry: Acts as a precursor or ligand in catalytic systems and organometallic complex synthesis.
• Polymer & Material Science: Employed in the development of specialty polymers, silicones, and functionalized materials requiring specific silyl or olefinic components.
• Cross-Coupling Reactions: The alkene group can participate in various metal-catalyzed cross-coupling reactions to form new carbon-carbon bonds.
• Protecting Group Strategy: The trimethylsilyl (TMS) group acts as a protecting group for the alcohol, which can be selectively deprotected under mild conditions.

Basic Information

Product Name	(E)-3-Trimethylsilanylbut-2-En-1-Ol
CAS No.	18269-58-4
Molecular Formula	C7H16OSi
Molecular Weight	144.29 g/mol
Synonyms	(E)-3-(Trimethylsilyl)-2-buten-1-ol; 3-Trimethylsilyl-2-buten-1-ol; (E)-3-(Trimethylsilyl)but-2-en-1-ol; 2-Buten-1-ol, 3-(trimethylsilyl)-, (E)-; (E)-3-(TMS)-2-buten-1-ol; TMS-but-2-en-1-ol; 3-Trimethylsilanyl-but-2-en-1-ol
EINECS	Contact for details

Quality Control

Our (E)-3-Trimethylsilanylbut-2-En-1-Ol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and specific impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C to maximize stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Isomeric Purity (E/Z ratio)	≥ 98:2 (E:Z)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.