Description

1-Chloro-4-Trimethylsilanyl-But-3-Yn-2-One is a specialized organosilicon building block featuring both a chloro and a trimethylsilyl-protected alkyne functional group. This unique bifunctional structure makes it a valuable intermediate for synthesizing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and advanced materials chemists for constructing novel molecular scaffolds, particularly in click chemistry and cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, especially those requiring alkyne or silicon-containing motifs.
• Agrochemical Synthesis: Used in the research and development of new pesticides, herbicides, and fungicides where its functional groups enable the creation of potent bioactive compounds.
• Material Science Research: Serves as a precursor for silicon-based polymers, dendrimers, and advanced organic-inorganic hybrid materials with tailored properties.
• Click Chemistry Reagent: The protected alkyne moiety is ideal for Huisgen cycloaddition (copper-catalyzed azide-alkyne cycloaddition) reactions, a cornerstone of bioconjugation and polymer chemistry.
• Cross-Coupling Reactions: Functions as a substrate in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form complex carbon-carbon bonds.
• Organic Synthesis Reagent: A versatile synthon in academic and industrial R&D labs for constructing complex natural products and fine chemicals.

Basic Information

Item	Details
Product Name	1-Chloro-4-Trimethylsilanyl-But-3-Yn-2-One
CAS No.	18245-82-4
Molecular Formula	C7H11ClOSi
Molecular Weight	174.70 g/mol
Synonyms	1-Chloro-4-(trimethylsilyl)-3-butyn-2-one; 4-(Trimethylsilyl)-1-chloro-3-butyn-2-one; 3-Butyn-2-one, 1-chloro-4-(trimethylsilyl)-; Chloro(trimethylsilyl)butynone; TMS-protected Chloroalkynone; 1-Chloro-4-trimethylsilylbut-3-yn-2-one
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Trimethylsilanyl-But-3-Yn-2-One is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee it meets your precise research and synthesis requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. For long-term stability, storage under an inert atmosphere (e.g., nitrogen or argon) is recommended. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.