Description

Thiobis(Hexamethyldisilazane) is a specialized organosilicon compound, also known as bis(trimethylsilyl)sulfide, that serves as a versatile silylating and sulfur-transfer agent. Its core value lies in its ability to efficiently introduce trimethylsilyl (TMS) groups and sulfur atoms into target molecules, enabling critical synthetic transformations and surface modifications. This high-purity reagent is essential for manufacturers and researchers in the pharmaceutical, semiconductor, and advanced materials sectors, where precise chemical functionalization is paramount.

Application

• Pharmaceutical Intermediate Synthesis: Used as a silylating agent to protect reactive functional groups (e.g., -OH, -NH) during the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Semiconductor Manufacturing: Employed in chemical vapor deposition (CVD) processes as a precursor for depositing silicon-containing thin films or for surface passivation.
• Surface Modification Agent: Functionalizes inorganic surfaces (e.g., silica, metals) to alter their hydrophobicity, adhesion, or compatibility with organic polymers.
• Catalyst and Ligand Preparation: Serves as a reagent for synthesizing sulfur-containing ligands or modifying catalysts used in organic and organometallic chemistry.
• Polymer Chemistry: Acts as a cross-linking agent or chain modifier in the production of specialty silicones and other polymers.
• Analytical Derivatization: Used to derivative polar compounds for Gas Chromatography (GC) or Gas Chromatography-Mass Spectrometry (GC-MS) analysis, improving volatility and detection.

Basic Information

Product Name	Thiobis(Hexamethyldisilazane)
CAS No.	18243-89-5
Molecular Formula	C12H36N2SSi4
Molecular Weight	348.86 g/mol
Synonyms	Bis(trimethylsilyl)sulfide; Hexamethyldisilazane sulfide; 1,1,1,3,3,3-Hexamethyl-2-[(trimethylsilyl)thio]-disilazane; N-(Trimethylsilyl)-S-(trimethylsilyl)thiohydroxylamine; HMDS Sulfide; TMS Sulfide; Sulfur bis(trimethylsilylamide)
EINECS	242-133-1

Quality Control

Our Thiobis(Hexamethyldisilazane) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including Gas Chromatography (GC) and Nuclear Magnetic Resonance (NMR) spectroscopy, to confirm identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, moisture content, and other critical parameters is provided with every shipment. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is highly volatile and hygroscopic (moisture-sensitive). Containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation from moisture and oxygen. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.1%
Refractive Index (n20/D)	1.450 - 1.455
Density (g/mL at 20°C)	0.85 - 0.90

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.