Description

tert-Butyldimethylsilanol is a versatile organosilicon compound primarily used as a key intermediate and protecting group reagent in organic synthesis. Its value lies in its ability to introduce the robust tert-butyldimethylsilyl (TBDMS) protecting group for alcohols and other functional groups, enabling complex multi-step syntheses. This makes it an essential material for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for protecting hydroxyl groups during complex reaction sequences.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides where selective protection of functional groups is required.
• Fine Chemical Manufacturing: Serves as a precursor for other silylating agents and specialty silanes used in various high-value chemical processes.
• Academic & Industrial R&D: A standard reagent in laboratory-scale organic synthesis for method development and the production of novel compounds.
• Material Science: Potential use as a surface modifying agent or a precursor in the development of silicon-based polymers and hybrid materials.

Basic Information

Product Name	tert-Butyldimethylsilanol
CAS No.	18173-64-3
Molecular Formula	C6H16OSi
Molecular Weight	132.28 g/mol
Synonyms	TBDMS-OH; tert-Butyldimethylhydroxysilane; (1,1-Dimethylethyl)dimethylsilanol; Dimethyl-tert-butylsilanol; 2,2-Dimethyl-1-silapropan-1-ol; TBS-OH; t-BuMe2SiOH; tert-Butyl(dimethyl)silanol
EINECS	242-060-2

Quality Control

Our tert-Butyldimethylsilanol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. For customers with specific requirements, we offer material produced under cGMP guidelines suitable for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent decomposition and maintain purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Melting Point	85 - 90 °C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.