Description

(3-Chloropropoxy)Trimethylsilane is a versatile organosilicon reagent featuring both a reactive chloropropyl group and a hydrolyzable trimethylsilyl (TMS) ether. This bifunctional nature makes it a valuable intermediate for introducing silyl-protecting groups and propyl linkers in sophisticated organic synthesis. It is particularly essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular modifications and controlled surface functionalization.

Application

• Pharmaceutical Intermediate: Used as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing spacer arms or silyl-protected functionalities.
• Surface Modification Agent: Employed to functionalize silica, glass, and other metal oxide surfaces, creating reactive sites for further chemical grafting in chromatography and nanotechnology.
• Polymer & Resin Synthesis: Acts as a monomer or cross-linking agent in the production of specialty silicones and hybrid organic-inorganic polymers.
• Protecting Group Chemistry: Serves as a reagent for the protection of alcohols and other hydroxyl-containing compounds via formation of TMS ethers, with a cleavable chloropropyl handle.
• Liquid Crystal & OLED Materials: Utilized in the synthesis of advanced electronic and optoelectronic materials requiring specific side-chain functionalization.
• Agrochemical Synthesis: A precursor in the manufacturing of certain herbicides and plant growth regulators that incorporate chloropropyl or siloxane motifs.

Basic Information

Product Name	(3-Chloropropoxy)Trimethylsilane
CAS No.	18171-15-8
Molecular Formula	C6H15ClOSi
Molecular Weight	166.72 g/mol
Synonyms	3-Chloropropyl Trimethylsilyl Ether; Trimethyl(3-chloropropoxy)silane; (3-Chloropropoxy)trimethylsilicon; 3-Chloro-1-(trimethylsilyloxy)propane; 1-Chloro-3-(trimethylsiloxy)propane; Silane, trimethyl(3-chloropropoxy)-; TMS-Protected 3-Chloropropanol; 3-Chloropropanol Trimethylsilyl Ether
EINECS	Contact for details

Quality Control

Our (3-Chloropropoxy)Trimethylsilane is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.425 - 1.430
Density (20°C)	0.95 - 0.99 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.