Description

3-Iodo-1-(Trimethylsilyl)Propane is a versatile organosilicon reagent featuring both an iodoalkyl and a trimethylsilyl protecting group. This compound is valued for its dual functionality, serving as a key building block in complex organic synthesis and advanced material science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing carbon-carbon bonds and silicon-containing molecular architectures.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly in cross-coupling reactions (e.g., Negishi, Kumada) to introduce propyl-linked functional groups.
• Agrochemical Synthesis: Serves as a precursor for creating novel pesticides and herbicides that require specific silicon-modified alkyl chains.
• Material Science: Employed in the preparation of functionalized silanes for surface modification, adhesion promoters, and silicone-based polymers.
• Organic Synthesis Reagent: Acts as a propyl anion equivalent or a masked nucleophile in multi-step synthetic sequences, leveraging the reactivity of the C-I bond and the stability of the TMS group.
• Liquid Crystal & OLED Research: Utilized in the development of organic semiconductors and liquid crystal materials where silicon and halogen atoms tune electronic and physical properties.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed couplings for the efficient construction of complex molecules in medicinal chemistry.

Basic Information

Product Name	3-Iodo-1-(Trimethylsilyl)Propane
CAS No.	18135-48-3
Molecular Formula	C6H15ISi
Molecular Weight	242.18 g/mol
Synonyms	(3-Iodopropyl)trimethylsilane; Trimethyl(3-iodopropyl)silane; 1-Trimethylsilyl-3-iodopropane; 3-Iodopropyltrimethylsilane; Silane, trimethyl(3-iodopropyl)-; TMS-propyl iodide; γ-Iodopropyltrimethylsilane
EINECS	Contact for details

Quality Control

Every batch of 3-Iodo-1-(Trimethylsilyl)Propane is manufactured and tested under strict quality management protocols. Our products undergo rigorous quality testing, including GC, NMR, and Karl Fischer titration, to ensure compliance with industry standards and precise customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C to maximize stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.