Description

Dimethoxyphosphoryl-Trimethyl-Silane is a versatile organophosphorus-silicon reagent, also known as trimethylsilyl dimethylphosphonate. This compound is valued for its dual functionality, serving as a key intermediate in the synthesis of complex organic molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily used by research chemists and process development scientists for the preparation of phosphonates and as a silylating agent in specialized organic transformations.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleotide analogs, antiviral agents, and other bioactive phosphonate-containing molecules.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that incorporate phosphonate or phosphonic acid ester moieties.
• Material Science Precursor: Acts as a starting material for the preparation of flame retardants, specialty polymers, and surface-modifying agents.
• Organic Synthesis Reagent: Employed as a phosphorylating and silylating agent in Horner-Wadsworth-Emmons (HWE) olefination reactions and other carbon-carbon bond-forming processes.
• Ligand and Catalyst Development: Useful for synthesizing novel phosphonate-based ligands for metal complexes used in catalysis.
• Laboratory Research: A valuable tool for academic and industrial R&D in medicinal chemistry and synthetic methodology development.

Basic Information

Product Name	Dimethoxyphosphoryl-Trimethyl-Silane
CAS No.	18135-14-3
Molecular Formula	C5H15O3PSi
Molecular Weight	182.24 g/mol
Synonyms	Trimethylsilyl Dimethylphosphonate; Dimethyl Trimethylsilyl Phosphite; Dimethoxy(trimethylsilyl)phosphine Oxide; O,O-Dimethyl (Trimethylsilyl)phosphonate; (Dimethoxyphosphoryl)trimethylsilane; Phosphonic acid, P-(trimethylsilyl)-, dimethyl ester; NSC 163083
EINECS	Contact for details

Quality Control

Our Dimethoxyphosphoryl-Trimethyl-Silane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.