Description

Trimethyl-(2-Trimethylsilylphenoxy)Silane is a specialized organosilicon compound that serves as a versatile building block and protective agent in advanced chemical synthesis. Its unique bifunctional structure, featuring both a siloxy and a silyl group, makes it a valuable reagent for introducing silicon-based functionalities and for the protection of phenolic hydroxyl groups under demanding conditions. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, reliable intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly where silicon is used as a traceless protecting group or to modulate drug properties.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its silicon groups can enhance stability or bioavailability.
• Polymer & Material Science: Acts as a monomer or cross-linking agent in the development of specialty silicones, siloxane-based polymers, and hybrid organic-inorganic materials.
• Surface Modification Agent: Employed to functionalize silica, glass, or other oxide surfaces, imparting specific hydrophobic or reactive properties.
• Silylating Agent: Used for the protection of sensitive phenolic hydroxyl groups in multi-step organic synthesis, offering stability under strong basic conditions.
• Research & Development: A critical reagent in academic and industrial R&D labs for exploring new organosilicon chemistry and developing novel synthetic methodologies.

Basic Information

Product Name	Trimethyl-(2-Trimethylsilylphenoxy)Silane
CAS No.	18036-83-4
Molecular Formula	C12H22OSi2
Molecular Weight	238.48 g/mol
Synonyms	2-(Trimethylsiloxy)phenyltrimethylsilane; Phenol, 2-(trimethylsilyl)-, trimethylsilyl ether; Bis(trimethylsilyl) Derivative of 2-Hydroxyphenyltrimethylsilane; (2-Trimethylsilylphenoxy)trimethylsilane; O-Trimethylsilyl-2-trimethylsilylphenol; TMS-Protected 2-Hydroxyphenyltrimethylsilane; 2-[(Trimethylsilyl)oxy]phenyltrimethylsilane
EINECS	Contact for details

Quality Control

Our production of Trimethyl-(2-Trimethylsilylphenoxy)Silane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and specific impurity profiles is provided with every shipment. We support compliance with cGMP and ISO 9001 standards for industrial and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is stable under inert atmosphere but may be sensitive to strong bases and moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.