Description

Trimethylsilylphosphorodichloridate is a highly reactive organosilicon reagent primarily used as a key phosphorylating and silylating agent in advanced chemical synthesis. Its dual functionality makes it a critical building block for constructing complex phosphorus-containing molecules with high precision and efficiency. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of nucleotide analogs, phosphoramidates, and novel organophosphorus ligands.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of prodrugs, antiviral agents (e.g., nucleotide analogs), and other bioactive phosphorus compounds.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators requiring specific phosphorus functionalities.
• Chemical Research: Serves as a versatile phosphorylating agent in organic and medicinal chemistry research for creating novel molecular scaffolds.
• Ligand & Catalyst Preparation: Building block for synthesizing specialized phosphite, phosphonite, and phosphate ligands used in homogeneous catalysis.
• Polymer Modification: Employed to introduce phosphorus and silicon groups into polymers to alter flame retardancy, adhesion, or other material properties.
• Protecting Group Chemistry: Utilized for the temporary protection of hydroxyl groups via silylation in multi-step synthetic sequences.

Basic Information

Product Name	Trimethylsilylphosphorodichloridate
CAS No.	18026-83-0
Molecular Formula	C3H9Cl2O3PSi
Molecular Weight	223.05 g/mol
Synonyms	Phosphorodichloridic Acid, Trimethylsilyl Ester; Dichloro(trimethylsiloxy)phosphine Oxide; Trimethylsilyl Phosphorodichloridate; TMS-P(O)Cl2; (Dichlorophosphoryloxy)trimethylsilane; O-Trimethylsilyl Phosphorodichloridate; NSC 241303
EINECS	Contact for details

Quality Control

Our Trimethylsilylphosphorodichloridate is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. We employ advanced analytical techniques including GC, NMR, and titration to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and highly volatile; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Chloride Content	31.5 - 32.5 %
Water Content (KF)	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.