Description

3-Methyl-1-(trimethylsilyl)-1-heptyn-3-ol is a specialized organosilicon compound featuring both a silyl-protected alkyne and a tertiary alcohol functional group. This unique bifunctional structure makes it a valuable versatile building block in advanced organic synthesis, particularly for constructing complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of complex drug candidates, leveraging the silyl group for protection-deprotection strategies and the alkyne for click chemistry or cross-coupling reactions.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, where its functional groups allow for the introduction of specific bioactive moieties.
• Material Science: Acts as a precursor for silicon-containing polymers or dendrimers, contributing to the development of specialty coatings, resins, or electronic materials.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing natural product analogs, ligands for catalysis, or other complex organic molecules via its reactive alkyne and alcohol sites.
• Cross-Coupling Reactions: The trimethylsilyl-protected alkyne can be selectively deprotected to generate terminal alkynes for Sonogashira and other palladium-catalyzed coupling reactions.

Basic Information

Product Name	3-Methyl-1-(trimethylsilyl)-1-heptyn-3-ol
CAS No.	17963-42-7
Molecular Formula	C11H22OSi
Molecular Weight	198.38 g/mol
Synonyms	1-Heptyn-3-ol, 3-methyl-1-(trimethylsilyl)-; 3-Methyl-1-(trimethylsilyl)-1-heptyn-3-ol; 1-(Trimethylsilyl)-3-methyl-1-heptyn-3-ol; TMS-Protected 3-Methyl-1-heptyn-3-ol; (3-Methyl-1-heptyn-3-yloxy)trimethylsilane; Trimethyl((3-methyl-1-heptyn-3-yl)oxy)silane
EINECS	Contact for details

Quality Control

Our production of 3-Methyl-1-(trimethylsilyl)-1-heptyn-3-ol adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including NMR, GC, and HPLC analysis, to confirm identity and purity. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment. We support custom synthesis and can tailor specifications to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.