Description

1-(Trimethylsilylethynyl)Cyclohexanol is a specialized organosilicon building block featuring a cyclohexanol core functionalized with a trimethylsilyl-protected alkyne group. This unique structure makes it a valuable intermediate in advanced organic synthesis, particularly for constructing complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications requiring precise carbon-carbon bond formation and silicon-based protecting group strategies.

Application

• Pharmaceutical Intermediate: Key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially those requiring alkyne coupling reactions (e.g., Sonogashira, Click chemistry).
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that incorporate silicon and alkyne functionalities.
• Material Science: Building block for creating silicon-containing polymers, dendrimers, and advanced organic frameworks with tailored properties.
• Organic Synthesis: Versatile reagent for introducing protected ethynyl groups into complex molecules, serving as a precursor for further functionalization.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological systems.

Basic Information

Product Name	1-(Trimethylsilylethynyl)Cyclohexanol
CAS No.	17962-22-0
Molecular Formula	C11H20OSi
Molecular Weight	196.36 g/mol
Synonyms	Cyclohexanol, 1-[(trimethylsilyl)ethynyl]-; 1-(Trimethylsilylethynyl)cyclohexan-1-ol; 1-Ethynyl-1-(trimethylsilyloxy)cyclohexane; 1-(2-Trimethylsilylethynyl)cyclohexanol; TMS-ethynylcyclohexanol; (1-Hydroxycyclohexyl)(trimethylsilyl)acetylene
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilylethynyl)Cyclohexanol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.