Description

4-Trimethylsilylbenzonitrile is a versatile organosilicon compound featuring a benzonitrile core functionalized with a trimethylsilyl group. This unique structure makes it a valuable protected intermediate and building block in advanced organic synthesis, particularly for the development of pharmaceuticals and functional materials. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require high-purity, reliable synthetic intermediates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring silicon-containing aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the silyl group modifies biological activity and stability.
• Material Science Precursor: Serves as a monomer or precursor for advanced polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl systems.
• Organic Synthesis Reagent: Used as a protected form of cyanobenzene or as a directing group in various metalation and functionalization reactions.
• Research & Development: A critical reagent in academic and industrial R&D for exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	4-Trimethylsilylbenzonitrile
CAS No.	17921-68-5
Molecular Formula	C10H13NSi
Molecular Weight	175.31 g/mol
Synonyms	p-(Trimethylsilyl)benzonitrile; 4-(Trimethylsilyl)benzonitrile; (4-Cyanophenyl)trimethylsilane; Benzonitrile, 4-(trimethylsilyl)-; TMS-benzonitrile; 4-TMS-benzonitrile; 4-Cyanophenyltrimethylsilane; 1-Cyano-4-(trimethylsilyl)benzene
EINECS	Contact for details

Quality Control

Our 4-Trimethylsilylbenzonitrile is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.