Description

Ethyl 2-(Trimethylsilymethyl)-Acetoacetate is a specialized organosilicon building block that combines the reactivity of an acetoacetate ester with the unique properties of a silyl group. This compound matters for its versatility as a key intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and material science industries for constructing novel silicon-containing frameworks.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those incorporating silicon to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the silicon moiety can enhance efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty silicone polymers and hybrid organic-inorganic materials.
• Organic Synthesis Building Block: Employed in various carbon-silicon bond forming reactions, including Peterson olefination and other nucleophilic substitution reactions.
• Ligand and Catalyst Development: Useful for synthesizing novel silicon-containing ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	Ethyl 2-(Trimethylsilymethyl)-Acetoacetate
CAS No.	17906-77-3
Molecular Formula	C10H20O3Si
Molecular Weight	216.35 g/mol
Synonyms	Ethyl (Trimethylsilyl)methyl Acetoacetate; Ethyl 2-[(Trimethylsilyl)methyl]-3-oxobutanoate; 3-Oxobutanoic acid, 2-[(trimethylsilyl)methyl]-, ethyl ester; Acetoacetic acid, (trimethylsilylmethyl)-, ethyl ester; Ethyl α-(Trimethylsilylmethyl)acetoacetate; ETMAA; TMSM-acetoacetate ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(Trimethylsilymethyl)-Acetoacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.