Description

3-Methyl-1-Trimethylsilyl-1-Pentyn-3-Ol (+/-) is a versatile organosilicon-protected acetylene derivative, serving as a key synthetic intermediate in advanced organic chemistry. Its primary value lies in its dual functionality, offering both a protected terminal alkyne and a tertiary alcohol group for selective transformations. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of complex drug molecules, particularly those requiring alkyne coupling reactions (e.g., Sonogashira) or silicon-based protecting group strategies.
• Agrochemical Synthesis: Used in the research and development of novel active ingredients, where its structural motifs can be incorporated into new fungicides or herbicides.
• Material Science Research: Serves as a precursor for silicon-containing polymers or dendrimers, contributing to the development of specialty coatings and advanced polymeric materials.
• Organic Synthesis Reagent: Employed in academic and industrial R&D labs for constructing complex carbon skeletons, natural product analogs, and molecular scaffolds.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Product Name	3-Methyl-1-Trimethylsilyl-1-Pentyn-3-Ol (+/-)
CAS No.	17889-43-9
Molecular Formula	C9H18OSi
Molecular Weight	170.32 g/mol
Synonyms	3-Methyl-1-(trimethylsilyl)-1-pentyn-3-ol; 1-Pentyn-3-ol, 3-methyl-1-(trimethylsilyl)-; 3-Methyl-1-trimethylsilylpent-1-yn-3-ol; (±)-3-Methyl-1-trimethylsilylpent-1-yn-3-ol; 3-Methyl-1-(trimethylsilyl)pent-1-yn-3-ol; TMS-protected 3-methylpentynol; Trimethyl(3-methyl-3-hydroxypent-1-yn-1-yl)silane
EINECS	Contact for details

Quality Control

Our production of 3-Methyl-1-Trimethylsilyl-1-Pentyn-3-Ol (+/-) adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. All materials are characterized using advanced analytical techniques including GC, HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after initial opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.