Description

3,5-Dibromo-1-Trimethylsilylbenzene is a versatile organosilicon intermediate featuring a brominated aromatic ring protected by a trimethylsilyl group. This compound is highly valued for its dual functionality, serving as a robust protecting group for phenols and as a precursor for further cross-coupling reactions, such as Suzuki or Negishi couplings. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing complex molecules and functionalized materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, leveraging its halogen atoms for further functionalization.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the silyl-protected phenol and bromine handles are crucial for structure-activity relationship (SAR) studies.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions to introduce the 3,5-dibromophenyl moiety into more complex molecular architectures.
• Protecting Group Chemistry: The trimethylsilyl group acts as a stable protecting group for phenols, which can be selectively deprotected under mild conditions.
• Chemical Research & Development: Essential for method development and exploring new synthetic pathways in academic and industrial research laboratories.

Basic Information

Product Name	3,5-Dibromo-1-Trimethylsilylbenzene
CAS No.	17878-23-8
Molecular Formula	C9H12Br2Si
Molecular Weight	308.09 g/mol
Synonyms	1,3-Dibromo-5-(trimethylsilyl)benzene; Trimethyl(3,5-dibromophenyl)silane; 3,5-Dibromophenyltrimethylsilane; Benzene, 1,3-dibromo-5-(trimethylsilyl)-; (3,5-Dibromophenyl)trimethylsilane; TMS-Protected 3,5-Dibromobenzene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Each batch is analyzed to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific test results are available upon request. We adhere to strict internal quality management protocols to guarantee the reliability of this high-value synthetic intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly closed and stored under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.