Description

Triisopropylsilanol is a versatile organosilicon compound, specifically a hindered silanol, valued for its role as a key intermediate and protecting group in sophisticated organic synthesis. Its sterically bulky structure provides unique reactivity and stability, making it essential for constructing complex molecular architectures. This high-purity chemical is primarily sought by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and advanced materials sectors for process development and scale-up.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block and protecting group in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly where steric hindrance is required.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its silicon-based functionality introduces desirable properties into the final molecule.
• Silylating Agent: Employed to introduce the triisopropylsilyl (TIPS) protecting group onto alcohols, phenols, and other sensitive functional groups in organic chemistry.
• Advanced Material Precursor: Acts as a monomer or modifying agent in the development of specialty silicones, silsesquioxanes, and other silicon-based polymers with tailored properties.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions, such as the Hiyama coupling, as an organosilicon reagent for carbon-carbon bond formation.
• Laboratory Research: A valuable reagent for medicinal chemistry and process chemistry teams in academic, government, and industrial R&D settings.

Basic Information

Product Name	Triisopropylsilanol
CAS No.	17877-23-5
Molecular Formula	C9H22OSi
Molecular Weight	174.36 g/mol
Synonyms	Triisopropylhydroxysilane; TIPS-OH; Hydroxytriisopropylsilane; Triisopropylsilyl alcohol; Silanol, triisopropyl-; 1-Hydroxytriisopropylsilane; Tri-iso-propylsilanol
EINECS	Contact for details

Quality Control

Our Triisopropylsilanol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Under these conditions, the product is stable for extended periods.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.