Description

Trimethylsilylbenzenesulfonate is a versatile organosilicon reagent and protecting group agent. This compound is valued for its role as a powerful silylating agent, particularly for introducing the trimethylsilyl (TMS) group onto oxygen and nitrogen atoms in complex synthetic pathways. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and efficient protection/deprotection strategies. Its properties make it a critical intermediate for fine chemical synthesis and process development.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key reagent in the protection of hydroxyl and amino groups during the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Employed in the production of advanced pesticides and herbicides where selective silylation is required for functional group manipulation.
• Peptide Chemistry: Acts as a silylating agent for the temporary protection of sensitive functional groups in solid-phase and solution-phase peptide synthesis.
• Natural Product Isolation & Derivatization: Facilitates the derivatization of complex natural products for analysis (e.g., GC-MS) or for synthetic modifications.
• Polymer & Material Science: Serves as a modifier or precursor in the synthesis of specialty silicones and silicon-containing polymers.
• Organic Synthesis Reagent: A versatile tool for chemists in academia and R&D for various transformations, including sulfonylation and as a Lewis acid catalyst component.

Basic Information

Product Name	Trimethylsilylbenzenesulfonate
CAS No.	17872-92-3
Molecular Formula	C9H14O3SSi
Molecular Weight	230.36 g/mol
Synonyms	Benzenesulfonic Acid Trimethylsilyl Ester; Trimethylsilyl Benzenesulfonate; Phenyltrimethylsilyl Sulfonate; TMS Benzenesulfonate; Trimethylsilyl Ester of Benzenesulfonic Acid; (Trimethylsilyloxy)benzenesulfonic Acid; TMS-OSO2Ph
EINECS	Contact for details

Quality Control

Our Trimethylsilylbenzenesulfonate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.