Description

3-Methyl-3-Trimethylsilyloxy-1-Butyne is a specialized organosilicon reagent featuring a protected alkynyl alcohol functionality. This compound matters as a versatile building block in advanced organic synthesis, enabling the controlled introduction of the 3-hydroxy-1-butyne moiety under mild conditions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediates: Key synthon for the synthesis of active pharmaceutical ingredients (APIs) and complex natural product analogs.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and plant growth regulators with tailored properties.
• Material Science Precursors: Used in the development of specialty polymers, dendrimers, and silicon-containing advanced materials.
• Organic Synthesis Reagent: Employed in Sonogashira coupling, nucleophilic addition, and other carbon-carbon bond-forming reactions.
• Protecting Group Strategy: The trimethylsilyloxy group serves as a protective group for alkynols, allowing selective transformations elsewhere in the molecule.
• Fine Chemical Manufacturing: Intermediate in the production of flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	3-Methyl-3-Trimethylsilyloxy-1-Butyne
CAS No.	17869-77-1
Molecular Formula	C8H16OSi
Molecular Weight	156.30 g/mol
Synonyms	3-Trimethylsilyloxy-3-methyl-1-butyne; 3-Methyl-3-((trimethylsilyl)oxy)-1-butyne; 1-Butyne, 3-methyl-3-[(trimethylsilyl)oxy]-; 3-Methyl-3-(trimethylsiloxy)-1-butyne; TMS-protected 3-methyl-3-butyn-1-ol; 3-Hydroxy-3-methyl-1-butyne trimethylsilyl ether
EINECS	Contact for details

Quality Control

Our 3-Methyl-3-Trimethylsilyloxy-1-Butyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the high standards required for research and commercial synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and oxygen. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.