Description

1-Trimethylsilyloxy-3-Butyne is a versatile organosilicon reagent featuring a protected terminal alkyne functionality. This compound is valued for its role as a key synthetic building block in advanced organic synthesis, enabling the introduction of the 3-butyne moiety under mild conditions. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring alkyne functional groups for coupling reactions like Sonogashira or click chemistry.
• Agrochemical Synthesis: Used in the production of advanced crop protection agents and herbicides where the alkyne unit is integral to the bioactive molecule's structure.
• Material Science: Serves as a monomer or precursor in the development of specialized polymers, dendrimers, and functionalized surfaces with tailored properties.
• Cross-Coupling Reactions: Acts as a stable, protected alkyne donor in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Organic Synthesis Reagent: Employed in academic and industrial R&D laboratories for the modular construction of complex natural products and novel organic compounds.
• Liquid Crystal & OLED Precursor: Utilized in the synthesis of organic electronic materials, where precise molecular architecture is critical for performance.

Basic Information

Product Name	1-Trimethylsilyloxy-3-Butyne
CAS No.	17869-75-9
Molecular Formula	C7H14OSi
Molecular Weight	142.27 g/mol
Synonyms	3-Butyn-1-ol, 1-(trimethylsilyloxy)-; 1-(Trimethylsilyloxy)-3-butyne; 3-Butynyloxytrimethylsilane; 3-Trimethylsilyloxy-1-butyne; TMS-Protected 3-Butyn-1-ol; (3-Butynyloxy)trimethylsilane; 3-Butyn-1-ol TMS ether; 1-Trimethylsiloxy-3-butyne
EINECS	Contact for details

Quality Control

Our 1-Trimethylsilyloxy-3-Butyne is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and FTIR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, keep containers tightly sealed when not in use and away from heat and ignition sources.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.